Middlesex County OPP say one person is dead after a vehicle collided with a transport truck on Dundas Street (Highway 2), west of Hunt Road.
Officers responded to the fatal crash at around 2:41 p.m. on Monday.
Police say the truck was travelling westbound on the roadway east of London, when it collided with an eastbound vehicle.
The lone occupant of the vehicle was pronounced dead on scene, police are withholding his identity pending notification of next of kin.
The driver was of the truck was not injured.
Police are continuing to investigate the crash and anyone with information is urged to contact them at 1-888-310-1122.